We observed that the HLA-A*11:01:01:01 [Pc = 0.013, OR = 2.26 (1.27–3.91)] allele and HLA-C*12:02:02:01-HLA-B*52:01:01:02 [Pc = 0.020, OR = 2.25 (1.24–3.92)] haplotype were significantly associated with the severity of COVID-19. Here, HLA-B is linked to COVID-19.