To understand the underlying mechanisms involved in the suppression of CD8+ T cell cytotoxic killing in endometrial tumors, we investigated whether there were changes in the expression of granzyme A (GZA), granzyme B (GZB), perforin (PRF), and PD-1 in CD103+ and CD103-CD8+ T cells. This evidence concerns the gene PRF1 and endometrium neoplasm.