As expected, PAH inhibited the expression of multiple ISGs genes (Cxcl10, Isg15, Isg56, and Ifit3) in the heart (Figure 6D), spleen (Figure 6E), stomach (Figure 6F), and tongue (Figure 6G) of Trex1−/− mice. This evidence concerns the gene ISG15 and pulmonary arterial hypertension.