AKT1 and breast cancer: PTEN dephosphorylates PtdIns(3,4,5)P 3 to form PtdIns(4,5)P 2 to negatively regulate PI3K/AKT signaling and has been shown to be related to the incidence of breast cancer and tumor progression (34, 35),Consistent with previous research data, TNBC is rich in PTEN mutations and PTEN exhibits low expression at the transcriptome level and is related to treatment resistance and poor survival (36).