FAT3 and melanoma: Interestingly, the results also showed that the three pathways of dorso-ventral axis formation, glioma, and melanoma were significantly enriched in the mutant group with FAT3 as the target gene (Figure 6B), while all five pathways were significantly active in the high TMB group, including basal transcription factors, DNA replication, homologous recombination, nucleotide excision repair, and Vibrio cholerae infection; no significant active pathway was found in the low TMB group (Figure 6C).