The research team divided the TNBC samples into a mutant group and a wild group based on eight mutant genes and found that the TMB of the mutant group in each subgroup was higher than that of the wild group.FAT3 encodes atypical cadherins (40); previous studies have shown that FAT3 has detected significant mutations in a variety of malignant tumors, such as breast cancer, lung adenocarcinoma, and small cell lung cancer (37, 41, 42). The gene discussed is CDH17; the disease is breast cancer.