In light of our recent findings that 1) Dsg3 exerts a function as an anti-stress protein via suppression of p53, ROS and apoptosis and 2) Dsg3 plays a role in regulating YAP (29, 37, 38), we hypothesized that altered YAP caused by oxidative stress might occur in PV. Here, TP53 is linked to acquired polycythemia vera.