It is possible that disruption of cell junctions by anti-Dsg1 antibodies also evokes YAP alterations due to the adhesive role of Dsg1 in desmosomes, as we also observed a moderate increase of YAP in pemphigus foliaceus but little or no changes in lichen planus, a chronic inflammatory, autoimmune condition in which cell junctions are much less affected (our unpublished data). The gene discussed is DSG1; the disease is lichen planus.