Therefore, our findings seem to be promising since the use of biosynthesized AgNPs is considered as an effective anticancer therapy (Firdhouse and Lalitha, 2013; Gajendran et al., 2014) while activation of macrophages can be involved in defense mechanism against tumors through lysis of cancer cells by liberating oxygen radicals and tumor necrosis factors (Klimp et al., 2002) or by controlling cancer through innate immunity, namely by stimulating the functions of T and B cells (Mills et al., 2016). Here, TNF is linked to cancer.