Compared with macrophage in Sham blood, NLRP3- (Sh Bl: 7843.50 ± 1219.12; 3 d Bl: 11769.61 ± 6224.95; 3 d Ip: 31003.80 ± 1760.71, P < 0.001) and IL1β-MFI (Sh Bl: 2420.50 ± 627.24; 3 d Bl: 6236.33 ± 4232.41; 3 d Ip: 6665.20 ± 311.82, P < 0.001) of blood macrophage at 3 days after stroke significantly elevated, which further increased when macrophage arrived at the stroke lesion (Ipsilateral brain) (Figure 4D), which indicated that inflammasome activation in macrophage began in peripheral blood but busted in the stroke lesion. This evidence concerns the gene NLRP3 and Stroke.