CAT and myocardial infarction: Additionally, it was shown that pretreatment with ursolic acid alleviates myocardial I/R, isoproterenol induces myocardial infarction (Radhiga et al., 2012), and doxorubicin induced cardiotoxicity (Mu et al., 2019) via several mechanisms: antiapoptotic effect on cardiomyocytes, anti-inflammatory effect, antioxidant effect through suppression of ROS formation, and enhancement of antioxidant protection [SOD, catalase (CAT), GSH] (Wang et al., 2018).