However, the expression levels of key genes (IKKα, IKKβ, IκBα, and p65) and MyD88 in the NF-κB signaling pathway were significantly increased by increase in dietary FSBM and SBM, indicating that the TLR-MyD88-NF-κB signaling pathway plays an important role in FSBM- and SBM-induced enteritis in the pearl gentian grouper. The gene discussed is NFKB1; the disease is enteritis.