The activation of NLRP3 inflammasome will deteriorate inflammation of pancreatitis (Hou et al., 2019; Sendler et al., 2020), and esults in production of IL-1β, IL-18 (Fan and Fan, 2018), and HMGB1 (Hou et al., 2018), which are associated with systemic injury. Here, IL18 is linked to pancreatitis.