STING1 and Aicardi-Goutieres syndrome: Cytoplasmic DNA triggers a STING-dependent inflammatory response and is associated with a variety of severe auto-inflammatory and immune diseases in humans (Ahn et al., 2012), such as Aicardi-Goutières Syndrome (AGS) (Pokatayev et al., 2016), Associated Vasculopathy With Onset in Infancy (SAVI) (Liu et al., 2014), and Systemic Lupus Erythematosus (SLE) (Kato et al., 2018).