TLR3 and Hyperglycemia: Besides, hyperglycemia can also inhibit the expression of IL-33, which is induced by IL-17 in keratinocytes through glycosylation, down-regulate Regenerating islet-derived protein 3A (REG3A), and up-regulate the expression of TLR3, supplementing REG3A can induce SHP-1 negatively regulating the TLR3-JNK2 signal axis to down-regulate TNF-α and IL-6, thereby improving chronic inflammation of DW (Wu et al., 2016).