It was found that S. glabra extract reduced the serum liver function indexes (ALT and aspartate aminotransferase (AST)), liver fibrosis indexes (hyaluronic acid (HA), procollagen type III (PC-III), procollagen type IV (C-IV) and laminin (LN)) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in rats with hepatic fibrosis induced by CCl4, as well as increasing the level of albumin (ALB). The gene discussed is GPT; the disease is Hepatic fibrosis.