IL1B and gout: Furthermore, based on our results, it is indicated that β-caryophyllene effectively reduced the inflammatory factor IL-1β in rat models of inflammatory arthritis, inhibited the assembly and activation of NLRP3 inflammasomes, as well as reduced the activities of Toll-like receptors and NF-κB pathways in gout rats, which conform to the previous studies (Chen et al., 2019; Irrera et al., 2019).