CYP2D6 and Parkinson disease: The mice with PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or pesticides like maneb and qaraquat, had the decreased mRNA expression of Cyp2d22 (homolog of human CYP2D6) in nigrostriatal tissues, while nicotine or resveratrol showed the neuroprotection via up-regulating Cyp2d22 expression (Singh et al., 2009; Srivastava et al., 2012), demonstrating the neuroprotective effects of CYP2D22/CYP2D6-mediated DA synthesis or neurotoxin metabolism (Fernandez-Abascal et al., 2018).