In addition, it has also been reported that CYP2E1 in brain can mediate the generation of reactive oxygen species (ROS) (Doycheva et al., 2019; Moyano et al., 2019) and regulate DA release, which are closely related to the pathogenesis of PD (Shahabi et al., 2008). The gene discussed is CYP2E1; the disease is Parkinson disease.