INS and diabetic kidney disease: For example, 5-HT3RA tropisetron shows renal protective effect on early diabetic nephropathy (Barzegar-Fallah et al., 2015) and improves pancreas function, increases insulin synthesis and secretion, and attenuates pancreas apoptosis in streptozotocin-induced diabetic rats (Naderi et al., 2020a; Naderi et al., 2020b).