As Table 3 shows, for the patients with CD4+ T lymphocyte deficiency (<410/μL) on admission, HDIVC exerted a significant improving effect (334 [191.9, 409.3] vs 151 [43.5, 240] P = 0.04), but not for the patients with deficiencies in CD8+ (190/μL) and lymphocytes on admission. The gene discussed is CD4; the disease is Nezelof syndrome.