Inhibition of cholinesterases (ChEs) to increase the amount of acetylcholine (ACh) has been acknowledged as the most effective treatment against Alzheimer’s disease (AD) since cholinergic projection is considered to be a major mechanism of AD pathogenesis (Isacson et al., 2002; Barnett, 2019). Here, BCHE is linked to early-onset autosomal dominant Alzheimer disease.