Given that LIG is the main component of the Chuanxiong Rhizoma and Angelica sinensis medicinal plants, which are widely used for the prevention and treatment of cardiovascular diseases in Southeast Asia and especially China (Peng et al., 2009), we assumed that LIG might prevent RE by targeting Gch1 to prevent the endothelial dysfunction caused by IR. This evidence concerns the gene GCH1 and endothelial dysfunction.