Protease-activated receptor 2 (PAR2) as a GPCR itself can facilitate Ca2+, MEK/ERK, AKT, PI3K and mTOR signaling pathways to promote a variety of tumor cell functions (Huang et al., 2013; Jiang et al., 2018; Tsai et al., 2018; Pawar et al., 2019). This evidence concerns the gene F2RL1 and neoplasm.