NSG1 and metabolic dysfunction-associated steatohepatitis: To investigate the underlying mechanism of the effects of GJ on the pharmacokinetics of SV and SVA in both healthy and NASH rats, the mRNA and protein levels of hepatic P-gp, Oatp1b2, and Cyp2c11 in rats from groups HC, HS, HSG1, NC, NS, and NSG1 were detected, as shown in Figure 4A.