In addition, such interactions might be further changed under NASH condition, given that OATP1B1/Oatp1b2, CYP3A4/Cyp2c11, and P-gp have been reported to be altered in NASH patients/animals (Donato et al., 2006; Hardwick et al., 2013; Canet and Cherrington, 2014). The gene discussed is CYP3A4; the disease is metabolic dysfunction-associated steatohepatitis.