Experimental studies have shown that fucose can significantly reduce the levels of pro-inflammatory factors IL-1β, IL-6, MPO and TNF-α in cerebral ischemia model animals, reduce the levels of oxidative stress-related proteins SOD and MDA, and could also regulate cell apoptosis via inhibiting the MAPK pathway to play a neuroprotective effect in cerebral ischemia reperfusion study (Che et al., 2017). The gene discussed is TNF; the disease is brain ischemia.