CYP20A1 and neoplasm: Tumor cell membrane phospholipids can release arachidonic acid (AA) through the action of phospholipase A2 (PLA2), then it was catalyzed to produce eicosanoids such as prostaglandins (PGE), leukotrienes and hydroxyeicosatetraenoic acid (HETEs) through the key enzymes from arachidonic acid metabolism network such as cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 monooxygenase, and further activates downstream signaling pathways such as PI3K/Akt.