CHCHD2 and amyotrophic lateral sclerosis: Perhaps the divergent disease phenotypes between CHCHD2 mutations and CHCHD10 mutations may in part be explained by their ability to associate with different pathological proteins such as α-synuclein (Ikeda et al., 2019; Imai et al., 2019a) and TDP-43 (Woo et al., 2017; Genin et al., 2019; Liu T. et al., 2020), respectively, the latter of which is a pathological hallmark of FTD-ALS (Neumann et al., 2006).