CHCHD10 and amyotrophic lateral sclerosis: In the aftermath of the discovery of CHCHD10 mutations in familial ALS-FTD patients (Bannwarth et al., 2014), Funayama and colleagues first reported two CHCHD2 missense mutations (T61I and R145Q) and one splice-site mutation (300 + 5G > A) in late-onset autosomal dominant PD in Japanese families (Funayama et al., 2015).