As CHCHD2 also interacts with cytochrome c and CHCHD2 dysfunction (loss of CHCHD2 or PD-linked mutations) increases cytochrome c release (Meng et al., 2017), such CHCHD2-mediated cytochrome c release may also drive increased α-synuclein oligomerization and aggregation. Here, CYCS is linked to Parkinson disease.