Therefore, the present investigation is to explore whether the downregulation of DHCR24 may induce an abnormality of membrane lipid raft-dependent PI3-K/Akt signaling, including downstream glycogen synthase kinase-3β (GSK3β) and mammalian target of rapamycin (mTOR) signaling, which are involved in the abnormal hyperphosphorylation of some tau sites in tauopathy. Here, MAPT is linked to tauopathy.