P-tau could self-assemble into soluble aggregates of oligomeric tau, paired helical filaments (PHF), straight filaments (SF), or neurofibrillary tangles (NFT), and also convert tau into a prion-like protein, which are critical events in the pathological progression of AD (Duka et al., 2013; Moszczynski et al., 2015; Alonso and Cohen, 2018). This evidence concerns the gene MAPT and Alzheimer disease.