Increasing data supported that the hyperphosphorylation of tau at several sites, such as Thr181, Ser199, Thr231, Ser262, Ser356, and Ser396, which are tightly associated with tauopathy in AD and other tauopathies (Sengupta et al., 1998; Duka et al., 2013; Neddens et al., 2018). The gene discussed is MAPT; the disease is tauopathy.