Abnormal activation of mTOR signaling have been recently implicated in the pathophysiology of AD and other neurodegenerative disease, including such as autophagy, tauopathy, and Aβ metabolism (Buller et al., 2008; Bhaskar et al., 2009; Zare-Shahabadi et al., 2015). This evidence concerns the gene MTOR and neurodegenerative disease.