C9orf72 and frontotemporal dementia: Additionally, the methylation of poly-GR reduces its propensity for LLPS and decreases toxicity in neurons, and symmetric dimethylation of poly-GR inclusions in C9orf72-FTD/ALS patient brain positively correlates with disease duration, suggesting methylation of poly-GR and reduced LLPS could be protective (Gittings et al., 2020).