Subsequently, activation of GSK3 would lead to a number of effects among which tau hyperphosphorylation (Ishiguro et al., 1993) and increased Aβ production through BACE1 activation (Ly et al., 2013) or APP phosphorylation (Rockenstein et al., 2007) could play a significant role in AD pathogenesis. Here, APP is linked to Alzheimer disease.