Regarding exenatide and cognitive outcome in AD rodent models, its use has been associated to memory improvement in i.c.v streptozotocin (STZ)-induced rats when treated during 2 weeks (Solmaz et al., 2015) and Bomba et al. (2013) showed that 3-month-old PS1-KI mice treated for 9 months with the GLP-1RA had improved performance in MWM while the 3xTg-AD assessed within the same protocol, did not show cognitive amelioration. Here, PSEN1 is linked to Alzheimer disease.