Interestingly, in a sporadic AD model, 12-month-old SAMP8 mice treated with metformin for 8 weeks, also exhibited an ameliorated behavioral profile with improved learning and memory parameters together with decreased levels of Aβ and p-Tau, even though pGSK3β was found to be slightly increased (Farr et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.