TNF and Alzheimer disease: XPro 1595 anti- TNF-α antibody rescued LTP, Aβ deposition and inflammatory response in 5xFAD (MacPherson et al., 2017) and the neutralization TNFSF10 pro-apoptotic cytokine belonging to TNF family was also able to improve spatial memory, decrease Aβ levels and inflammation in the hippocampus of 3xTG-AD mice (Cantarella et al., 2015).