APP and Alzheimer disease: For instance, KD exposed 3xTg-AD mice exhibited enhanced memory and learning ability in addition to decreased hippocampal Aβ deposition (Kashiwaya et al., 2013), while APP/V7/171 transgenic female mice also showed decreased levels of Aβ along with positive metabolic changes in response to KD, though the behavioral alterations were not significantly improved (Van der Auwera et al., 2005).