Authors have recently found not only an improvement of metabolic parameters associated to dyslipidemia and insulin resistance in the periphery but also central insulin signaling was improved in the hypothalamus and prefrontal cortex, together with behavioral changes in anxiety-like behavior (De Sousa Rodrigues et al., 2019), reinforcing the potential of anti-inflammatory strategies in metabolic- and brain-dysfunction contexts. This evidence concerns the gene INS and Insulin resistance.