Furthermore, we also showed that Ang-(1-7)/Mas activation in the brain is capable of reducing cardiac hypertrophy and pre-fibrotic lesions and decreasing the altered imbalance of Ang II/Ang-(1-7) in the heart of hypertensive transgenic rats (mRen2)27 (Kangussu et al., 2015). This evidence concerns the gene AGT and cardiac hypertrophy.