AGT and Hypertension: Among the main pathophysiological mechanisms of arterial hypertension is the hyperactivity of the renin-angiotensin system (RAS), characterized by an increase in Ang II in plasma and tissue concentration, as previously reported in these hypertensive transgenic rat model (Bader et al., 1992; Campbell et al., 1995; Nakagawa and Sigmund, 2017).