AKT1 and cancer: Another compound observed to inhibit the growth of cancer cells is cedrol (IC50 = 44.36 ± 0.9 μg/ml toward C32 human amelanotic melanoma cells; 41.06 ± 0.7 μg/ml toward ACHN human renal cell adenocarcinoma cells), which was shown to increase intracellular ROS production and induce autophagy and apoptotic cell death through the PI3K/Akt signaling pathway in A549 non-small cell lung carcinoma cells 35, 36.