PTGS2 and eosinophilia-myalgia syndrome: Lee el. proposed that p38MAPK which was phosphorylated by IL-1 was expressed in both ectopic and eutopic endometrium and stimulated inflammatory cells to secrete more interleukin-6 (IL-6), interleukin-8 (IL-8), COX-2 and other inflammatory mediators in EMs patients 34.