Western blotting showed that, compared with the CON group, p75NTR (Fig. 6a), Bax (Fig. 6b), p53 (Fig. 6c), cleaved caspase-3 (Fig. 6d), and p-JNK (Fig. 6e) were overexpressed in pups from the SCH and OHT groups. The gene discussed is MAPK8; the disease is spindle cell hemangioma.