Western blotting showed that compared with the CON group, expression of p-TrkA (Fig. 5a, b), p-ERK1/2 (Fig. 5c, d), and p-CREB (Fig. 5e, f) were decreased in the hippocampus of offspring from SCH and OHT rats (all p < 0.05), but the total protein levels had no significant differences, respectively (all p > 0.05, Fig. 5c, f, i). Here, CREB1 is linked to spindle cell hemangioma.