RNF123 downregulation results in a p50 decrease, which reduces the amount of the transcriptional inactive p50 dimers regulator, thereby promoting tumor growth and metastasis.4,5 The histone epigenomic marks were assessed to determine regulatory regions controlling RNF123 expression in epidermal primary melanocytes and metastatic melanoma cell lines (COLO829, SK-MEL5, and RPMI7951) and glioblastoma cell lines (H54, M059J, and A172) (Fig. 1). The gene discussed is RNF123; the disease is metastatic melanoma.