First, we analyzed the expression profiles of CXCR4 and DR5 by using UCSC Xena (https://xena.ucsc.edu/) browser in a panel of breast cancer cell lines and GDC TCGA Breast Cancer (BRCA) patient cohort (Figs. 7A, B) and found inverse correlation between CXCR4 and DR5 expression in most of the breast cancer cell lines as well as in a large number of human breast cancer tissues. This evidence concerns the gene CXCR4 and breast carcinoma.