BCL2 and neoplasm: It is not clear if GANT61 in combination with chloroquine or 5Z could dramatically improve their antitumor activity in vivo in a mouse tumor xenograft model; Fourth, the mechanisms by which autophagy antagonizes GANT61-induced apoptosis remain to be investigated (Fig. 6C); Fifth, it is well known that NF-κB activation leads to Bcl-2 expression and confers resistance to apoptosis in tumor cells24,46.