AXIN2 and lung adenocarcinoma: We found that expression of a positive regulator of Wnt signaling Frizzled (FZD)9 and DVL1 was negatively correlated with FTO expression whereas expression of negative regulators of Wnt signaling APC, GSK3β, and AXIN2 was positively correlated with FTO expression in lung adenocarcinoma (Fig. 2I).