Correspondingly, FTO depletion resulted in increased glucose uptake (Figs. 5C, S5E), lactate production (Figs. 5D, S5F), cell proliferation (Figs. 5E, S5G, H), cell growth in soft agar (Figs. 5F, S5I), migration, and invasion (Figs. 5G, S5J) of the tumor cells; these increases were all inhibited by c-Myc depletion. The gene discussed is FTO; the disease is neoplasm.