HNF4A and lung adenocarcinoma: To determine the mechanism underlying the downregulation of FTO in lung adenocarcinoma cells, we analyzed the FTO promoter sequence with PROMO software and identified three potential LEF/TCF-binding elements (TBE) (Fig. S2A) that are closely located and can be recognized by the β-catenin/LEF/TCF complex in response to Wnt signaling37–40.