Several significantly changed genes at this timepoint have been associated with AD-like pathology and disease progression (BCL2L2, CHST8, CLEC7A, CYP27A, CYP7B1, DAPK1, GPR34, MERTK, OLFML3, SUMO1, TTR, TYROBP), cognitive impairment (DAPK1, EXO1, RELN, SUMO1, TYROBP), PD progression (SUMO1, MAPK10), and the accumulation of toxic proteins (DAPK1, MAPK10, MSR1, OLFML3, SUMO1, TYROBP). The gene discussed is EXO1; the disease is Parkinson disease.