Several significantly changed genes at this timepoint have been associated with AD-like pathology and disease progression (BCL2L2, CHST8, CLEC7A, CYP27A, CYP7B1, DAPK1, GPR34, MERTK, OLFML3, SUMO1, TTR, TYROBP), cognitive impairment (DAPK1, EXO1, RELN, SUMO1, TYROBP), PD progression (SUMO1, MAPK10), and the accumulation of toxic proteins (DAPK1, MAPK10, MSR1, OLFML3, SUMO1, TYROBP). This evidence concerns the gene SUMO1 and Parkinson disease.