F3 and thrombophilia: Lambrianides et al. reported that only aPL from patients with vascular thrombosis but no obstetric morbidity stimulates the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and p38 mitogen-activated protein kinase and increases tissue factor activity in monocytes, thus associated with hypercoagulability in APS [34].