TLR4 and Candidemia: Increased susceptibility to systemic fungal complications, such as candidemia was linked to polymorphisms of Interleukin 10 (IL-10) (rs1800896) [40], Toll-like receptors 1 (TLR-1) (rs5743611, rs4833095, rs5743618) [41], Toll-like receptors 2 (TLR-2) [42], caspase recruitment domain-containing protein 9 (CARD9) (G72S,R373P,Q295X) [43, 44], Toll-like receptors 4 (TLR-4) (rs4986790,rs4986791) [45], and Dectin-1 [46] since 2006.