Though in the majority of cases, RFX1 acts as a negative regulator of metastasis, it has been reported that the transcriptional activity of RFX1 was doubled in a metastatic ovarian cancer cell line HO-8910PM compared to its parent cell line, suggesting a positive role of RFX1 in cancer metastasis [72]. This evidence concerns the gene RFX1 and ovarian carcinoma.