RFX1 reduces cancer cell proliferation by targeting FGF1 [7] and transforming growth factor beta 2 (TGFβ2) [8], induce differentiation by targeting CD44 [2] and c-Myc [9], and promote apoptosis by regulating myeloid cell leukemia sequence 1 protein (MCL1) [10]. Here, RFX1 is linked to cancer.