In breast cancer cell lines MDA-MB-468 and MCF-7, the IL-6/STA3 pathway plays a crucial role in EMT by upregulating TGF-β [66], a multifactorial cytokine that is again a target of RFX1 and a downstream signaling molecule of CD44 in breast cancer cells [67]. The gene discussed is ARHGEF3; the disease is breast cancer.