Considering decreased expression of Fli1 and RALDH1 in CD11c+ cells as shown in our previous and current studies and exclusive expression of RALDH in cDCs [9, 11], we can plausibly conclude that Fli1 deficiency induces SSc-like phenotypes in dermal DCs, in addition to previously shown fibroblasts, endothelial cells, macrophages and epithelial cells [22, 30, 31, 33, 39, 40]. Here, ITGAX is linked to systemic sclerosis.