However, our recent study identified aldehyde dehydrogenase 1 family member A1 (ALDH1A1/RALDH1)-producing CD103−CD11b− cDCs as a critical DC subset regulating the development of inducible Foxp3+ regulatory T cells (Tregs) in BLM-treated mice and demonstrated decreased numbers of RALDH1-producing dermal DCs in SSc involved skin [9]. Here, ALDH1A1 is linked to systemic sclerosis.