Findings demonstrating HIF-1α regulation by microRNA in UM have been reported by Xia and colleagues, who evidenced promotion of HIF-1α signaling and migration of UM cell by miR-652 through the repression of HOXA9 [252], a negative regulator of HIF-1 expression in cutaneous squamous cell carcinoma [253]. Here, HIF1A is linked to cutaneous squamous cell carcinoma.