HIF1A and neoplasm: A study carried out by Jager group’s on about 60 patients enucleated for UM and corroborated by data on 80 patients from the Cancer Genome Atlas reported no correlation between HIF-1α expression and basal diameter or tumour thickness, while HIF-1α expression was found positively related with endothelial marker CD31 and with enhanced infiltration of T cells and macrophages.