Moreover, while a correlation between VEGF serum levels and metastatic disease has been identified in UM patients identifying VEGF as a biomarker for metastatic UM [262], no association between VEGF-A expression and histopathological characteristics or occurrence of metastasis or metastases-free survival was demonstrated, probably due to the small number of samples or to the short follow-up [242, 261]. This evidence concerns the gene VEGFA and metastatic neoplasm.