HIPK2 expression was found to be higher in RA synovial tissues and RA-FLSs (Fig. 5c-f); meanwhile, when we elevated miR-129-5p level by transfecting miR-129-5p mimic into RA-FLSs (Fig. 5g), the expression of HIPK2 showed a marked decrease in miR-129-5p-upregulated RA-FLSs (Fig. 5h, i). The gene discussed is HIPK2; the disease is rheumatoid arthritis.