The results of subgroup analysis indicated that patients with higher PD-L1 expression had poorer PFS in the following subgroups: tumor proportional score (TPS) of scoring system subgroup (HR = 3.12; 95% CI = 1.28–3.89; P = 0.000; Fig. 3a), sample size larger than 100 patients (HR = 2.96; 95% CI = 1.72–5.09; P = 0.000; Fig. 4a), and 22C3 IHC antibodies (HR = 2.96; 95% CI = 1.94–4.1; P = 0.000; Fig. 5a). Here, CD274 is linked to neoplasm.