HAVCR2 and hepatocellular carcinoma: The study by Peng-Fei Zhang et al. proved that HCC-derived exosomal circUHRF1 up-regulate the expression of exo-miR-449c-5p target gene TIM-3 in NK cells by degrading miR-449c-5p, thereby promoting immune escape and anti-PD1 immunotherapy resistance in HCC [115].