AFP and hepatocellular carcinoma: Alpha-fetoprotein the most commonly used serologic test item, but in retrospective case-control studies, even with the most effective threshold (10–20 ng/mL), the reported sensitivity was around 60 % and specificity was only 80 % [8, 9].The main treatment options for HCC are surgical resection, transplantation, ablation, transarterial chemoembolization [10–12], and drug therapy such as sorafenib [13, 14], levatinib [15], and regorafenib [16].