In triple network, the regulatory relationships between miRNA, TF, mRNA regulating networks and up-regulated cysteine cathepsin family genes were found, SP1-CTSD-(has-miR-24-3p) and SP1-CTSB-(has-miR-128-3p) from the TF-mRNA-miRNA network were identified as playing a potentially critical regulatory role in CHD (Fig. 7c). Here, CTSD is linked to coronary artery disorder.