Size of the tumor, presence of lymphovascular invasion, and the quantitative assessment of Ki-67 reactive cells, Mitosis index, together with tumor differentiation, and grade help to determine prognosis, although no absolute criteria for determining the malignant potential of extrahepatic NETs have been published to this date; generally, they have a 10-year survival of 80% [7]. This evidence concerns the gene MKI67 and neoplasm.