SAR1B and chylomicron retention disease: Indeed, no significant hepatic lipid accumulation and abnormal lipid metabolism were observed despite genetically modified Sar1b. Nevertheless, the little impact of Sar1b mutations on VLDL delivery by the liver of patients with CRD and mice compared with McArdle-RH7777 hepatocytes (20) is an intriguing issue, which needs clarifications in future investigations.