More work on the mechanisms underlying small bowel Crohn-related metaplastic changes is certainly needed; however, their apparent relevance for both origin and progression of associated cancers seems worth additional investigation, also considering the putative role played by CK7 in other gastrointestinal diseases, such as Barrett’s oesophagus [47, 48], a known metaplastic carcinogenic lesion, and colorectal cancer [34, 35]. This evidence concerns the gene KRT7 and gastrointestinal disease.