Finally, the most interesting novel somatic mutations that occurred on trunks and branches were activating mutations of the RAS GTPases KRAS and HRAS that predispose to non‐ossifying fibromas [11] and malignant giant cell tumors of the bone [12, 13] but have not been reported in osteosarcoma thus far. The gene discussed is KRAS; the disease is osteosarcoma.