Since the importance of PD-L1 has already been established as personalized medicine target in other tumor entities (Sun et al. 2018; Honda et al. 2017; Kataoka and Ogawa 2016; Kataoka et al. 2016; Isaacsson Velho and Antonarakis 2018; Fan et al. 2019; Reck et al. 2016; Li et al. 2016; Fujita et al. 2015) our findings in glioma may also open new therapeutic approaches in future brain tumor therapy. Here, CD274 is linked to central nervous system cancer.