TMEM116 and melanoma: This analysis implicated Fut7, Mgat5, Pcdh7, Tmem116, and olfactory receptors (ORs) Olfr441 and Olfr322 as drivers of pulmonary metastasis in melanoma cells, with gRNAs targeting the TSSs of these genes being found in the 98th percentile of relative abundance of gRNAs present in the lungs of ≥13/40 mice.